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Updated: Jun 20, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Postpartum depression, suicidality, and mother-infant interactions.

Ruth Paris1, Rendelle E Bolton, M Katherine Weinberg

  • 1Boston University School of Social Work, 264 Bay State Road, Boston, MA 02215, USA. rparis@bu.edu

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Summary

Women with postpartum depression and high suicidality show more severe symptoms and poorer mother-infant interactions. This highlights the need for integrated mental health support for mothers and their infants.

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Area of Science:

  • Perinatal Mental Health
  • Psychiatry
  • Developmental Psychology

Background:

  • Limited research exists on suicidality in women with postpartum depression (PPD).
  • Previous studies show varied rates of suicidal ideation in postpartum women.
  • No studies have explored the link between suicidality and mother-infant interactions in PPD.

Purpose of the Study:

  • To examine suicidality in a clinical sample of women with PPD.
  • To investigate the relationship between suicidality and maternal mood, perceptions, and parenting stress.
  • To analyze the impact of maternal suicidality on mother-infant interactions.

Main Methods:

  • Utilized baseline data from a multi-method evaluation of home-based psychotherapy for PPD.
  • Assessed maternal mood, cognitive distortions, PPD symptom severity, self-esteem, and parenting stress.
  • Observed and rated mother-infant interactions for sensitivity, responsiveness, and infant affect.

Main Results:

  • Women with high suicidality (compared to low) exhibited greater mood disturbances, cognitive distortions, and PPD symptom severity.
  • High suicidality was associated with lower maternal self-esteem, negative relationship perceptions, and increased parenting stress.
  • Mothers with high suicidality were less sensitive and responsive; their infants showed less positive affect and involvement.

Conclusions:

  • Suicidality in PPD is linked to significant maternal distress and impaired mother-infant interactions.
  • Findings underscore the importance of addressing suicidality in PPD for maternal and infant well-being.
  • Clinical practice should integrate assessment of suicidality and its impact on the dyadic relationship.