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Determination of reference values for the soluble transferrin receptor (sTfR) on a cross sectional population sample
Alexa von Schmiesing1, Stefan A Schmidt, Wolfgang Kratzer
1Universitätsklinikum Ulm, Zentrale Einrichtung für Klinische Chemie, Albert-Einstein-Allee 23, 89070 Ulm, Germany.
Background:
Aim of the study was to determine reference values for the soluble Transferrin Receptor (sTfR) in a cross sectional population sample.
Methods:
For the determination of reference values, using a standard calibrated fluorescence-immunoassay, the samples (990 females; 1060 males; 13 - 65 years old) were divided into five groups according to age and sex. Soluble transferrin receptor and ferritin were measured by a fluorescence-immunoassay with AIA-21 (TOSOH BIOSCIENCE, Tessenderlo, Belgium). The sTfR/logFer-Index was calculated by dividing the sTfR by the logarithm of ferritin, the logsTfR/Fer-Index by dividing the logarithm of sTfR by ferritin.
Results:
Mean sTfR concentration was 1.75 +/- 0.39 mg/l in group I (13-17 years), 1.65 +/- 0.34 mg/l in group II (18-30 years), 1.60 +/- 0.39 mg/l in group III (31-40 years), 1.54 +/- 0.39 mg/l in group IV (41-50 years), and 1.59 +/- 0.34 mg/l in group V (51-65 years), respectively. A gender-specific difference between the groups was observed: sTfR concentrations were lower in group I (p < 0.005) and group II (p = 0.01) for women. The mean sTfR-concentration decreased consecutively in the age group I-IV (13-50 years).
Conclusions:
This is the first cross sectional population based study to determine reference values for sTfR-concentrations. Our results demonstrated age- and gender-specific differences.
