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Updated: Jun 20, 2026

Oligopeptide Competition Assay for Phosphorylation Site Determination
Published on: May 18, 2017
Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?
Manu Vatish1, Eijiro Yamada, Jeffrey E Pessin
1Albert Einstein College of Medicine, Diabetes Research and Training Center, Department of Medicine, Bronx, NY 10461, USA.
Abstract:
The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.
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