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Related Experiment Video

Updated: Jun 20, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Biomarkers in fibromyalgia.

Jacob N Ablin¹, Dan Buskila, Daniel J Clauw

¹University of Michigan Chronic Pain and Fatigue Research Center, Ann Arbor, MI 48106, USA.

Current Pain and Headache Reports

|September 5, 2009

Summary

Fibromyalgia, a widespread pain condition, shows objective abnormalities pointing to central nervous system dysfunction. Research is identifying potential biomarkers for tracking disease progression and treatment response.

Area of Science:

Neuroscience
Rheumatology
Pain Medicine

Background:

Fibromyalgia is a prevalent pain syndrome with widespread pain and tenderness.
Initial skepticism regarding objective abnormalities has given way to reproducible findings.
Central nervous system (CNS) dysregulation is increasingly recognized as a key pathogenic mechanism.

Purpose of the Study:

To review objective abnormalities and measures identified in fibromyalgia.
To identify promising biomarkers for monitoring treatment response and disease progression.

Main Methods:

Literature review of studies identifying objective measures in fibromyalgia patients.
Analysis of identified abnormalities for their potential as biomarkers.

Related Experiment Videos

Last Updated: Jun 20, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Main Results:

Multiple objective abnormalities have been reproducibly identified in fibromyalgia.
These findings predominantly suggest CNS dysregulation.
Several measures show promise as potential biomarkers.

Conclusions:

Objective measures confirming CNS dysregulation in fibromyalgia are established.
Further research can validate these measures as biomarkers for clinical utility.