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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Hyperpolarized Xenon for NMR and MRI Applications
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Published on: September 6, 2012

Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system.

N Amor1, P P Zänker, P Blümler

  • 1Max Planck Institute for Polymer Research, 55128 Mainz, Germany.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|September 5, 2009
PubMed
Summary

A new method uses hollow fiber membranes to continuously produce hyperpolarized Xenon-129 (Xe) solutions for MRI. This technique enables better imaging of lung ventilation and perfusion, showing potential for clinical applications.

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Area of Science:

  • Medical Imaging
  • Nuclear Magnetic Resonance (NMR)
  • Materials Science

Background:

  • Hyperpolarized Xenon-129 (Xe) MRI offers unique insights into lung function.
  • Producing stable, high-concentration Xe solutions for in vivo MRI remains a challenge.
  • Existing methods can suffer from foam and bubble formation, impacting image quality.

Purpose of the Study:

  • To develop and evaluate a continuous production technique for hyperpolarized Xe solutions for MRI.
  • To investigate various carrier agents for their efficacy as in vivo MRI contrast agents.
  • To demonstrate the application of this method for lung MRI, assessing ventilation and perfusion.

Main Methods:

  • Utilized hollow fiber membranes to prevent foam and bubble formation during Xe dissolution.
  • Systematically analyzed different carrier agents for hyperpolarized Xe.
  • Compared image quality of various hyperpolarized Xe solutions.
  • Acquired MRI data in both clinical and non-clinical settings.
  • Demonstrated lung phantom imaging using dissolved and outgassed Xe.

Main Results:

  • The hollow fiber membrane technique successfully produced stable solutions of hyperpolarized Xe.
  • Identified effective carrier agents for in vivo MRI applications.
  • Achieved comparable image quality across different Xe solutions.
  • Successfully imaged a lung phantom, showcasing potential for lung ventilation and perfusion measurement.

Conclusions:

  • The developed dissolution method provides a continuous and stable source of hyperpolarized Xe for MRI.
  • This technique holds significant promise for advancing lung MRI applications, including perfusion and ventilation assessments.
  • The use of hollow fiber membranes is a key innovation for overcoming previous limitations in Xe solution preparation.