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A model of quantitative traits under frequency-dependent balancing selection.

G S Mani1, B C Clarke, P R Shelton

  • 1Department of Theoretical Physics, Schuster Laboratory, University of Manchester, U.K.

Proceedings of the Royal Society of London. Series B, Biological Sciences
|May 22, 1990
PubMed
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A computer model simulates stabilizing and frequency-dependent selection, explaining natural variation and maintaining genetic diversity. This model differs from neutral theories by linking population size to heterozygosity.

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Quantitative genetics

Background:

  • Natural populations exhibit significant phenotypic and genotypic variation.
  • Understanding the evolutionary forces maintaining this variation is a central challenge in population genetics.

Purpose of the Study:

  • To develop and analyze a computer model simulating selection on quantitative traits.
  • To investigate mechanisms for the maintenance of genetic variability in populations.

Main Methods:

  • A computer model was developed to simulate stabilizing and frequency-dependent selection.
  • The model incorporates quantitative characters influenced by multiple genetic loci.
  • Model robustness was assessed concerning selection function shape and frequency dependence.

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Main Results:

  • The model's outcomes align with observed natural variations at phenotypic and genotypic levels.
  • Results demonstrate robustness, with minimal dependence on specific selection function parameters.
  • A mechanism for maintaining substantial genetic variability was identified.

Conclusions:

  • The model provides a plausible explanation for the maintenance of genetic diversity.
  • It establishes a relationship between population size and heterozygosity, consistent with natural observations.
  • This model offers an alternative to purely neutral explanations for genetic variation.