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Mutational order: a major stochastic process in evolution.

G S Mani1, B C Clarke

  • 1Department of Theoretical Physics, Schuster Laboratory, University of Manchester, U.K.

Proceedings of the Royal Society of London. Series B, Biological Sciences
|May 22, 1990
PubMed
Summary
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Random mutation order significantly drives evolutionary divergence between populations. This process, distinct from genetic drift, highlights how mutation randomness shapes distinct evolutionary paths even under identical conditions.

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Computational biology

Background:

  • Evolutionary divergence is typically attributed to genetic drift and differing selective pressures.
  • The role of mutation order in shaping population divergence under selection is less understood.

Purpose of the Study:

  • To investigate the impact of mutation randomness on evolutionary divergence in computer simulations.
  • To differentiate the effects of mutation order from random genetic drift.

Main Methods:

  • Computer simulations modeling selection on quantitative characters.
  • Analysis of evolutionary trajectories under identical initial conditions and selection pressures.

Main Results:

  • Randomness in mutation occurrence and fixation significantly contributes to population divergence.

Related Experiment Videos

  • Mutational order can be a primary driver of divergence, exceeding random genetic drift in large populations or under strong selection.
  • A disconnection between phenotypic and genotypic evolution was observed, alongside an episodic, selection-driven molecular clock.

    • Conclusions:

    • The stochastic nature of mutations, specifically their order, plays a crucial role in evolutionary divergence.
    • Mutation order's impact is contingent on population size and selection strength, distinct from random genetic drift.
    • This mechanism provides a novel perspective on molecular evolution and the emergence of evolutionary novelty.