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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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The use of fibrin glue in plastic surgery

Eric Mooney1, Cecilia Loh, Lee L Q Pu

  • 1Cooperstown, N.Y.; and Sacramento, Calif. From Bassett Healthcare, and the Division of Plastic Surgery, University of California, Davis.

Plastic and Reconstructive Surgery
|September 5, 2009
PubMed

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.