Related Experiment Video
Updated: Jun 20, 2026

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
Published on: February 24, 2026
[Intrathecal baclofen therapy. Overdose during replacement of a medication pump]
K Kramer1, M Weber, A Koulousakis
1Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln, Köln. kathrin.kramer@uk-koeln.de
Abstract:
This case report reviews the anesthesiological complications of intrathecal baclofen (ITB) therapy. An 11-year-old boy with spasticity and apallic syndrome needed general anesthesia for exchange of a baclofen pump but 2 h later he became increasingly hypothermic, hypotonic with bradycardy and dyspnea. The cause was an intra-operative bolus of ITB. Reduction of the baclofen administration rate caused disappearance of all symptoms without any residual effects. The ITB is an increasingly used therapeutic option for multiple sclerosis and cerebral palsy. Therefore, emergency personal and anesthesiologists must be aware of the possible side effects of this medication.
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