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Updated: Jun 20, 2026

Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

Appetite is a heritable phenotype associated with adiposity.

Jane Wardle1, Susan Carnell

  • 1Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, Gower Street, WC1E 6BT, London, UK, j.wardle@ucl.ac.uk.

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine
|September 5, 2009
PubMed
Summary

Genetically influenced appetite traits increase obesity risk in obesogenic environments. These heritable appetite signals, like satiety responsiveness, are key to understanding weight regulation and susceptibility to environmental factors.

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Last Updated: Jun 20, 2026

Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Area of Science:

  • Behavioral genetics
  • Obesity research
  • Nutritional science

Background:

  • Adiposity (body fatness) is highly heritable.
  • Environmental factors interact with genetics in obesity development.
  • Shifting distribution of adiposity over time suggests complex etiology.

Purpose of the Study:

  • Investigate genetically determined appetite differences.
  • Examine appetite's role in susceptibility to obesogenic environments.
  • Understand variation in weight regulation.

Main Methods:

  • Review of published behavioral and psychometric studies.
  • Analysis of twin studies on heritability of appetitive traits.
  • Examination of genetic associations (e.g., FTO gene).

Main Results:

  • Appetitive traits (satiety responsiveness, cue sensitivity) differentiate weight groups.
  • Heritability of appetitive traits is high.
  • Sensitivity to satiety cues is linked to the FTO gene, mediating its effect on weight.

Conclusions:

  • Heritable appetite signaling increases overeating risk in obesogenic environments.
  • Appetitive traits are phenotypes influencing obesity susceptibility.
  • A behavioral model explains high heritability and environmental responsiveness of weight.