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Updated: Jun 20, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
[Progressive supranucleair palsy: acetylcholineeserase-inhibitor a possible therapy?]
1Klinisch geriater, GeheugenCentrum, Jeroen Bosch Ziekenhuis,'s Hertogenbosch. h.nijboer@JBZ.nl
Abstract:
Progressive supranucleair palsy (PSP) is a serious neurologic disease which is seldom diagnosed due to its complexity. In 1996 international diagnostic criteria were developed by a group of experts, the diagnosis remains complicated. We describe three cases, which were followed in the period 2001-2008. In these case reports we elaborate on the therapeutic use of rivastigmine. During off-label rivastigmine use, patients showed minimal further cognitive decline, specifically with respect to frontal defects. However, larger studies and trials are necessary to explore the effects of rivastigmine in patients with PSP.
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