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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative
Yuan Gao1, Yi Kuang, Zu-Feng Guo
1Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.
Abstract:
By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
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