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10:42
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent.
Yan Li1, Solene Le Maux, Hang Xiao
1Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Journal of Agricultural and Food Chemistry
|September 8, 2009
Summary
Tributyrin emulsions, stabilized with corn oil, show promise for colon cancer prevention. These food-grade delivery systems effectively inhibited colon cancer cell viability in lab tests.
Area of Science:
- Nutraceuticals and Food Science
- Cancer Prevention Research
- Biotechnology and Drug Delivery
Background:
- Tributyrin, a food additive, is a potential colon cancer preventive agent.
- Developing stable, food-grade delivery systems for tributyrin is crucial for its application.
- Existing tributyrin emulsions face instability issues like Ostwald ripening.
Purpose of the Study:
- To create stable, food-grade oil-in-water emulsions for tributyrin delivery.
- To improve the stability of tributyrin emulsions against Ostwald ripening.
- To evaluate the anticancer potential of these novel tributyrin delivery systems.
Main Methods:
- Formulation of oil-in-water emulsions with tributyrin and varying corn oil concentrations.
- Assessment of emulsion stability, focusing on Ostwald ripening and droplet sedimentation.
- Evaluation of tributyrin emulsion efficacy using HT29 colon carcinoma cell cultures.
Main Results:
- Incorporating 15-25% corn oil significantly enhanced emulsion stability against Ostwald ripening.
- Mixed tributyrin/corn oil emulsions exhibited reduced droplet sedimentation.
- Tributyrin-containing emulsions demonstrated significant inhibition of HT29 colon carcinoma cell viability.
Conclusions:
- Food-grade tributyrin-in-corn oil emulsions offer a stable delivery system.
- These emulsions show potential as anticancer agents, particularly for colon cancer.
- The findings support the development of nutraceuticals in food-grade delivery systems for cancer prevention.
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