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Published on: May 15, 2019
Bortezomib: a new therapeutic option for POEMS syndrome
Isik Kaygusuz1, Hakan Tezcan, Mustafa Cetiner
1Department of Hematology, Marmara University School of Medicine, Marmara University, Istanbul, Turkey. isikkaygusuz@yahoo.com
Objective:
POEMS syndrome with its classical five findings (Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin changes) is a rare multisystem disease. Proinflammatory and proangiogenic cytokines play important roles in its pathogenesis. Treatment options are still debated.
Methods:
We present a 65-year-old man with POEMS syndrome who was successfully treated with bortezomib.
Results:
After seven cycles of this protocol, serum M protein level declined to normal range, and near-to-complete remission was achieved. His symptoms of polyneuropathy improved dramatically.
Conclusion:
Bortezomib may be an effective and safe therapeutic option for patients with POEMS syndrome.
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