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Related Experiment Videos

Developments in pertussis immunisation in Japan.

M Kimura1, H Kuno-Sakai

  • 1Department of Paediatrics, School of Medicine, Tokai University, Kanagawa, Japan.

Lancet (London, England)
|July 7, 1990
PubMed
Summary
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Japan

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Acellular pertussis vaccines have been used in Japan since 1981.
  • Whole-cell pertussis vaccines were previously used.

Purpose of the Study:

  • To evaluate the impact of acellular pertussis vaccine introduction in Japan.
  • To compare adverse reaction rates between acellular and whole-cell pertussis vaccines.

Main Methods:

  • Observational study comparing pertussis incidence and mortality before and after vaccine switch.
  • Retrospective comparison of adverse event data for whole-cell (1973-74) and acellular (1979-80) vaccines.

Main Results:

  • A steady decline in pertussis cases and deaths observed since 1979.

Related Experiment Videos

  • Acellular pertussis vaccine showed lower rates of fever and local reactions compared to whole-cell vaccine.

    • Conclusions:

    • The introduction of acellular pertussis vaccine in Japan has been associated with reduced pertussis incidence and mortality.
    • Acellular pertussis vaccine demonstrates an improved safety profile with fewer adverse reactions.