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Do children undergoing cancer procedures under pharmacological sedation still report pain and anxiety? A preliminary
Alexandra Dufresne1, Marc-André Dugas, Yvan Samson
1Department of Pediatrics, Universite Laval, Quebec, Canada.
Insights
Intravenous sedation effectively reduces children's procedural pain and fear. However, children still anticipate anxiety, and parents experience significant anxiety. Hypnosis may offer additional benefits for managing procedural anxiety in children and parents.
Area of Science:
- Pediatric Anesthesiology
- Pain Management
- Child Psychology
Background:
- Needle-based procedures in children often induce significant pain and fear.
- Intravenous sedation-analgesia is commonly used to manage procedural pain and anxiety.
- The effectiveness of non-pharmacological interventions alongside sedation requires further investigation.
Purpose of the Study:
- To quantify children's pain and fear levels during needle puncture procedures.
- To evaluate the efficacy of intravenous sedation-analgesia in reducing procedural distress.
- To assess the potential role of non-pharmacological interventions, such as hypnosis, in managing pediatric procedural anxiety.
Main Methods:
- A cohort of 14 children undergoing needle puncture procedures were assessed.
- Pain and fear were measured using the Visual Analog Scale (VAS) by children, parents, and physicians before and during procedures.
- Intravenous sedation-analgesia (midazolam/ketamine) was administered during the procedures.
Main Results:
- Sedation significantly reduced children's pain and fear levels during procedures.
- Children's self-reported pain during sedation did not correlate with parent or physician ratings.
- Children who anticipated higher pain and fear experienced greater distress during the procedures.
- Parents reported significant pre-procedural anxiety, which did not correlate with their children's fear.
Conclusions:
- Intravenous sedation-analgesia is effective in mitigating children's procedural pain and fear.
- Children's anticipatory anxiety remains a concern despite sedation.
- Parents experience considerable anxiety related to their child's procedures.
- Hypnosis presents a promising adjunctive therapy for managing anxiety in both children and parents during medical procedures.
Objectives:
We aimed to quantify children's levels of pain and fear during needle puncture procedures in a context where intravenous sedation-analgesia seems to be effective for pain and anxiety relief. The relevance of a nonpharmacological intervention in the pharmacological regimen was evaluated.
Design:
Fear and pain were assessed by children, parents and physicians, on a visual analog scale (VAS, 0-10 cm), before and during puncture procedures. Higher scores represented more intense pain/fear.
Results:
During 4 consecutive months, 18 children were recruited, but four were excluded from analyses because they did not receive the full sedation regimen (midazolam/ketamine) (N = 14, mean age +/- SD: 9.9 +/- 3.4 years). Parents self-reported their own anxiety before the procedure (4.69 +/- 3.17), but no correlation was found with their children's self-reported fear. Before procedures, the children's fear was self-reported on a VAS by children (2.93 +/- 2.93), parents (4.45 +/- 2.87), and physicians (3.67 +/- 2.48). During procedures under sedation, the children's pain (1.71 +/- 2.74) did not correlate with the parents' (4.01 +/- 3.23) and physicians' (1.83 +/- 2.32) ratings. Children anticipating high levels of pain and fear on the VAS experienced higher levels of pain (r = 0.65, P < 0.05) and fear (r = 0.59, P < 0.05) during the procedures. Sixteen parents (16/18) agreed to participate with their children if a study evaluating hypnosis for pain and anxiety was conducted.
Conclusions:
Sedation is effective in lowering levels of fear and pain in children during procedures, but they still anticipate fear before the procedures. Parents are anxious for their children. Future hypnotic intervention could be helpful for children as well as parents to cope with anxiety during procedures.
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