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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: Jun 20, 2026

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

Inflammatory breast cancer.

Wendy A Woodward1, Massimo Cristofanilli

  • 1Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Seminars in Radiation Oncology
|September 8, 2009
PubMed
Summary
This summary is machine-generated.

Inflammatory breast cancer (IBC) is an aggressive breast cancer requiring a multidisciplinary approach. Multimodality treatment, including neoadjuvant chemotherapy, surgery, and radiation, is crucial for improving outcomes in this virulent disease.

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Published on: January 8, 2018

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer.
  • It is characterized by skin involvement and rapid disease progression.
  • Effective management requires a coordinated multidisciplinary approach.

Purpose of the Study:

  • To examine the unique epidemiology and pathology of IBC.
  • To review current and emerging treatment modalities for IBC.
  • To emphasize the significance of a multimodality approach in managing IBC.

Main Methods:

  • Review of existing literature on IBC epidemiology, pathology, and treatment.
  • Analysis of the role of neoadjuvant chemotherapy in improving survival.
  • Discussion of the critical importance of locoregional therapies (surgery, radiation).

Main Results:

  • Neoadjuvant chemotherapy has significantly improved overall survival for IBC patients.
  • Locoregional therapies, including surgery and radiation, are vital for continued improvement.
  • A multimodality approach integrating imaging, chemotherapy, surgery, and radiation is standard.

Conclusions:

  • A comprehensive, multimodality treatment strategy is essential for managing inflammatory breast cancer.
  • Continued research into systemic therapies holds promise for further improving patient outcomes.
  • Understanding IBC's unique characteristics is key to optimizing patient care.