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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Videos

Lymphoma: which chemotherapy protocol and why?

Ruthanne Chun1

  • 1University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI 53706, USA. chunr@svm.vetmed

Topics in Companion Animal Medicine
|September 8, 2009
PubMed
Summary

Doxorubicin-based chemotherapy, like CHOP, is the most effective treatment for canine lymphoma, offering the longest disease control and survival. Prolonged maintenance is not advised, but consolidation therapy may help.

Area of Science:

  • Veterinary Oncology
  • Hematologic Neoplasms
  • Canine Cancer Therapy

Background:

  • Lymphoma is the most common hematologic neoplasm in dogs.
  • Doxorubicin-based chemotherapy protocols (e.g., CHOP) are widely considered the standard of care for canine lymphoma.
  • Treatment protocols, including drug sequencing and maintenance phases, show considerable variation among oncologists.

Purpose of the Study:

  • To summarize current literature on chemotherapy for canine high-grade lymphoma.
  • To provide evidence-based recommendations for various therapeutic scenarios.
  • To discuss the role of consolidation therapy and alternative treatments like radiation and bone marrow transplant.

Main Methods:

  • Literature review of existing studies on canine lymphoma chemotherapy.

Related Experiment Videos

  • Analysis of treatment protocols, including drug combinations, radiation, and bone marrow transplantation.
  • Synthesis of data to formulate therapeutic recommendations.

    • Main Results:

    • Doxorubicin-based combination chemotherapy (CHOP) provides the longest disease control and survival for dogs with lymphoma.
    • Prolonged maintenance chemotherapy is generally not recommended.
    • Consolidation therapy may offer benefits in specific cases.

    Conclusions:

    • Doxorubicin-based chemotherapy remains the cornerstone for treating canine lymphoma.
    • Treatment strategies should be tailored to individual cases, considering consolidation therapy and potential adjuncts.
    • Further research may refine optimal protocols for canine lymphoma.