Related Experiment Video
Updated: Jun 20, 2026

Models of Bone Metastasis
Published on: September 4, 2012
Predictive value of osteocalcin in bone metastatic differentiated thyroid carcinoma
Yunchao Gao1, Hankui Lu, Qiong Luo
1Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. gaookok@163.com
Objectives:
To evaluate the diagnostic value of serum osteocalcin in the detection of bone metastases from differentiated thyroid carcinoma (DTC).
Design And Methods:
Serum samples from DTC patients with (DTC BM+, n=19) or without bone metastases (DTC BM-, n=19), and matched healthy volunteers (n=30) were tested for serum osteocalcin with electrochemiluminescent immunoassay.
Results:
Osteocalcin was higher in DTC BM+ than in DTC BM- patients (+35.8%, p=0.002), acting as an independent risk factor for bone metastases (R(2)=0.142, p=0.039). The sensitivity was 78.9% and the specificity was 63.2% at a cut-off value of 11.2 microg/L.
Conclusions:
Serial measurements of osteocalcin could be useful in the detection of bone metastases from DTC.
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