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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
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[Muscular metastasis].

S Mathis1, G Fromont-Hankard, F du Boisguéheneuc

  • 1Service de neurologie, CHU de Poitiers, université de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France. s.mathis@chu-poitiers.fr

Revue Neurologique
|September 8, 2009
PubMed
Summary
This summary is machine-generated.

Muscular metastasis from cancer are rare but often present as a painful mass, typically in the lower limbs. Early detection via muscle biopsy is crucial for identifying the primary cancer and improving prognosis.

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Area of Science:

  • Oncology
  • Pathology
  • Musculoskeletal System

Background:

  • Neoplasia within myology is uncommon, with muscular metastases infrequently documented in cancer cases.
  • This study reviews existing literature and presents a case of muscular metastasis presenting as limited mouth opening.

Observation:

  • A retrospective analysis identified 174 cases of cancer with muscular metastasis.
  • Most cases occurred in males (2:1 ratio) with a mean age of 58.5 years.
  • Metastases were rarely found before cancer diagnosis (37%) and often appeared during disease progression (60%).

Findings:

  • Muscular metastases typically manifest as a solitary (78%), painful (61%), palpable mass (63%), predominantly in the lower limbs (46%).
  • Common primary cancer sites include lung, urinary, digestive, and genital tracts.
  • Prognosis is poor, with survival rates below 2.5% beyond 72 months.

Implications:

  • Highlights the significance of investigating focal, painful, and palpable muscular masses for potential metastasis.
  • Muscle biopsy and immunohistochemistry are valuable tools for determining the primary cancer origin.
  • Emphasizes the need for increased awareness and diagnostic focus on rare muscular metastases in oncology.