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Published on: October 17, 2018
Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis
1Department of Neurology, Myongji Hospital, Kwangdong University College of Medicine, 697-24, Hwajung Dukyang, Goyang, Gyeonggi 412-270, Republic of Korea. neurodasan@paran.com
Clinical Neurology and Neurosurgery
|September 8, 2009
Summary
Microscopic polyangiitis (MPA) rarely causes cerebrovascular issues. This case highlights MPA presenting with multiple non-hemorrhagic cerebral infarctions during steroid pulse therapy.
Area of Science:
- Rheumatology
- Neurology
- Vascular Medicine
Background:
- Microscopic polyangiitis (MPA) is a systemic small vessel vasculitis.
- Cerebrovascular disease is an uncommon complication of MPA, typically presenting as hemorrhage.
Observation:
- A 66-year-old woman with diagnosed MPA developed multiple bilateral non-hemorrhagic cerebral infarctions.
- The patient was undergoing steroid pulse therapy for MPA.
Findings:
- The MPA diagnosis was confirmed by painful mononeuritis multiplex, pulmonary fibrosis, elevated myeloperoxidase, and sural nerve biopsy.
- This case demonstrates a rare presentation of MPA with ischemic stroke.
Implications:
- This case expands the spectrum of neurological complications associated with microscopic polyangiitis.
- Highlights the importance of considering ischemic cerebrovascular events in MPA patients, even during treatment.
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