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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
Pathogenesis of bovine brucellosis
Alcina V Carvalho Neta1, Juliana P S Mol, Mariana N Xavier
1Escola de Veterinária, Universidade Federal de Minas Gerais. Av. Antônio Carlos, 6627, 30123-970 Belo Horizonte, MG, Brazil.
Veterinary Journal (London, England : 1997)
|September 8, 2009
Summary
Bovine brucellosis, a zoonotic disease caused by Brucella abortus, leads to significant economic losses in cattle. Understanding its pathogenesis and host immune responses is crucial for disease control.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Immunology
Background:
- Bovine brucellosis is a significant zoonotic disease causing economic losses globally, particularly in developing nations.
- Caused by Brucella abortus, the disease manifests as reproductive failure in cows and respiratory issues in calves.
- Pathological lesions include placentitis, mastitis, and pneumonia.
Purpose of the Study:
- To review the pathogenesis of Brucella abortus.
- To examine the bacterium's mechanisms for evading host defenses.
- To discuss the host's innate and adaptive immune responses to brucellosis.
Main Methods:
- Literature review focusing on Brucella abortus pathogenesis.
- Analysis of bacterial invasion strategies (phagocytic and non-phagocytic cells).
- Review of immune evasion tactics (intraphagosomal survival, inhibition of phagosome-lysosome fusion).
Main Results:
- Brucella abortus invades various host cells, facilitating its survival and spread.
- The pathogen employs mechanisms to resist host cell degradation, including survival in acidified phagosomes.
- Inhibition of phagosome-lysosome fusion is a key strategy for intracellular persistence.
Conclusions:
- Brucella abortus possesses sophisticated mechanisms to overcome host immune defenses.
- Understanding these pathogenic strategies is vital for developing effective control measures.
- Further research into innate and adaptive immunity is essential for combating bovine brucellosis.
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