Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRPV1 Agonist Capsaicin Enhances Oxidative-Stress Resistance and Regeneration in Dorsal Root Ganglia and Schwann Cells.

Cells·2026
Same author

Attitudes of specialist memory-clinic patients with early symptomatic Alzheimer's disease towards lecanemab: results from a multicenter survey in Europe.

Scientific reports·2026
Same author

Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.

Nature neuroscience·2026
Same author

Hnrnpa1 is essential for early zebrafish development and lipid metabolism: insights from a novel zebrafish knockout model.

Frontiers in cell and developmental biology·2026
Same author

A Novel 3D Semi-Automated Full Quantification Technique for Detection of Intraneural Phospho-α-Synuclein in Skin Biopsies.

European journal of neurology·2026
Same author

Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection.

eGastroenterology·2026

Related Experiment Video

Updated: Jun 20, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Mitochondrial dysfunction in Parkinson's disease.

Konstanze F Winklhofer1, Christian Haass

  • 1German Center for Neurodegenerative Diseases (DZNE) Munich and Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany. Konstanze.Winklhofer@med.uni-muenchen.de

Biochimica Et Biophysica Acta
|September 8, 2009
PubMed
Summary

Mitochondrial dysfunction is central to Parkinson's disease (PD) pathogenesis. Multiple PD-associated genes impact mitochondrial health, suggesting a common pathway for both familial and sporadic forms of the disease.

Related Experiment Videos

Last Updated: Jun 20, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Area of Science:

  • Cell Biology
  • Neuroscience
  • Mitochondrial Biology

Background:

  • Mitochondria are vital organelles involved in energy metabolism, calcium homeostasis, stress response, and cell death.
  • Mitochondrial dysfunction is implicated in cellular damage, aging, and neurodegenerative disorders.
  • Evidence links mitochondrial dysfunction to the pathogenesis of Parkinson's disease (PD).

Purpose of the Study:

  • To explore the role of mitochondrial dysfunction in Parkinson's disease.
  • To investigate the connection between PD-associated genes and mitochondrial pathways.
  • To understand how familial and sporadic PD converge at the level of mitochondrial integrity.

Main Methods:

  • Review of existing literature on mitochondrial function and Parkinson's disease.
  • Analysis of studies linking PD-associated genes to mitochondrial dynamics and integrity.
  • Synthesis of evidence for a common convergence point in PD pathogenesis.

Main Results:

  • Inhibitors of mitochondrial complex I can induce parkinsonism.
  • Several genes associated with PD regulate mitochondrial function, morphology, and dynamics.
  • Both sporadic and familial Parkinson's disease appear to converge on mitochondrial integrity.

Conclusions:

  • Mitochondrial dysfunction is a key factor in the development of Parkinson's disease.
  • Genetic factors in PD significantly influence mitochondrial health.
  • Maintaining mitochondrial integrity is crucial for understanding and potentially treating Parkinson's disease.