Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improved myocardial preservation during cold storage using substrate enhancement.

C K Haan1, H L Lazar, S Rivers

  • 1Department of Cardiothoracic Surgery, Boston University Medical Center, Massachusetts.

The Annals of Thoracic Surgery
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selecting oversized donor cardiac allografts for patients with pulmonary hypertension may be unnecessary.

Transplantation proceedings·2014
Same author

T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica).

Journal of comparative pathology·2014
Same author

Minimally invasive versus conventional aortic valve replacement: a 10-year experience.

The Journal of cardiovascular surgery·2010
Same author

Robotic assisted thoracic surgery for resection of an esophageal cyst.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2006
Same author

The benefits of support group participation to lung cancer survivors--an evaluation.

Clinical lung cancer·2004
Same author

Developing an interdisciplinary evidence-based skin care pathway for long-term care.

Advances in skin & wound care·2002

Adding L-glutamate to reperfusate solutions improved ventricular function in transplanted hearts after cold storage. This substrate enhancement is key for better recovery of heart transplant outcomes.

Area of Science:

  • Cardiology
  • Transplantation Biology
  • Biochemistry

Background:

  • Organ preservation for transplantation is critical.
  • Cold storage can impair post-transplant cardiac function.
  • Substrate enhancement strategies are being explored to improve outcomes.

Purpose of the Study:

  • To investigate the effect of L-glutamate on ventricular function recovery in transplanted rabbit hearts.
  • To determine optimal timing and application of L-glutamate during preservation and reperfusion.

Main Methods:

  • Rabbit hearts were preserved using hypothermic cardioplegia and cold storage.
  • Hearts were divided into groups receiving L-glutamate in various solutions (cardioplegia, reperfusate, or both).
  • Ventricular function was assessed by measuring left ventricular pressure changes and compliance post-reperfusion.

Related Experiment Videos

Main Results:

  • L-glutamate addition to reperfusate solutions significantly improved recovery of left ventricular pressure dynamics.
  • Groups receiving L-glutamate in reperfusate showed the best functional recovery.
  • L-glutamate pretreatment alone did not enhance recovery compared to controls.

Conclusions:

  • L-glutamate in reperfusate solutions enhances ventricular function recovery after cold storage in transplanted hearts.
  • This finding suggests L-glutamate is a beneficial substrate for cardiac preservation during transplantation.
  • Optimizing reperfusate composition with L-glutamate may improve clinical heart transplant success.