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Commitment is the  process whereby stem cells:
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Notch Signaling Pathway03:14

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Lineage commitment: cytokines instruct, at last!

E Richard Stanley1

  • 1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. rstanley@aecom.yu.edu

Cell Stem Cell
|September 8, 2009
PubMed
Summary
This summary is machine-generated.

Hematopoietic cytokines can instruct lineage choice, according to new research. This finding supports instructive models over permissive models of cell commitment in hematopoiesis.

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Area of Science:

  • Hematology
  • Cell Biology
  • Developmental Biology

Background:

  • Cell commitment in hematopoiesis has been explained by instructive and permissive models.
  • Hematopoietic cytokines are key regulators of blood cell development.

Purpose of the Study:

  • To investigate the role of hematopoietic cytokines in directing cell lineage choice.
  • To differentiate between instructive and permissive models of cell commitment.

Main Methods:

  • Analysis of data from Rieger et al. (2009) and Sarrazin et al. (2009).
  • Review of studies published in Science and Cell.

Main Results:

  • Cytokines actively instruct hematopoietic stem cells towards specific lineages.
  • Evidence supports an instructive role for cytokines in lineage determination.

Conclusions:

  • Hematopoietic cytokines play a crucial role in instructing cell lineage choice.
  • The findings favor instructive over permissive models of cell commitment.