Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 20, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Newly developed Sr-substituted alpha-TCP bone cements.

S Pina1, P M Torres, F Goetz-Neunhoeffer

  • 1University of Aveiro, Department of Ceramics and Glass Engineering, CICECO, 3810-193 Aveiro, Portugal.

Acta Biomaterialia
|September 8, 2009
PubMed
Summary

Researchers developed new bone cements using Sr-substituted alpha-TCP and tested their properties. They found that these cements form apatite in simulated body fluid, suggesting they can mineralize like natural bone. Heat release during setting showed a two-stage process, with initial reactions within 10-15 minutes and a second peak after an hour. Sr-substituted cements had higher compressive strength in wet conditions than non-substituted ones. The study suggests these materials could be useful in orthopedic applications, such as filling bone defects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists" [Bioact. Mater. 40 (2024) 104-147].

Bioactive materials·2025
Same author

Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.

Bioactive materials·2024
Same author

[Report template from the German Society of Urology and the German Radiological Society for standardized, structured reporting of native computed tomography scans in the diagnosis of urinary stones].

Urologie (Heidelberg, Germany)·2023
Same author

Characterization data of reference materials used for phase II of the priority program DFG SPP 2005 "Opus Fluidum Futurum - Rheology of reactive, multiscale, multiphase construction materials".

Data in brief·2023
Same author

Structural and impedance spectroscopy characteristics of BaCO<sub>3</sub>/BaSnO<sub>3</sub>/SnO<sub>2</sub> nanocomposite: observation of a non-monotonic relaxation behavior.

RSC advances·2022
Same author

Osteogenic lithium-doped brushite cements for bone regeneration.

Bioactive materials·2022

Area of Science:

  • Orthopedic biomaterials development
  • Calcium phosphate cement characterization
  • Biomedical mineralization studies

Background:

Current bone cement formulations lack sufficient mineralization properties for long-term stability. While traditional calcium phosphate cements (CPCs) have been used in orthopedic applications, their performance in simulated biological environments remains limited. Prior research has shown that brushite-forming cements can convert into apatite under physiological conditions. However, the rate and extent of this conversion are not fully understood. No prior work had resolved how strontium substitution affects cement properties during mineralization. This gap motivated researchers to explore Sr-substituted alpha-TCP as a novel material. The study aimed to determine if strontium incorporation could enhance in vitro mineralization. The findings could guide future material design for orthopedic implants.

Purpose Of The Study:

Researchers aimed to evaluate the mineralization potential of Sr-substituted alpha-TCP cements. They focused on how strontium affects cement behavior during setting and hardening. The specific problem addressed was the lack of durable bone cements with strong in vitro mineralization. The motivation came from clinical needs for materials that mimic natural bone formation. The team sought to trace the setting process and apatite formation in these cements. They also wanted to measure compressive strength changes over time. The goal was to assess whether Sr-substitution improves cement performance. This could lead to better materials for orthopedic use.

Keywords:
bone cement mineralizationstrontium substituted cementsapatite formation processorthopedic biomaterials

Frequently Asked Questions

The study found that Sr-substituted cements form apatite in simulated body fluid, suggesting in vitro mineralization capability.

It tracks heat release during cement setting, revealing exothermic reactions within 10-15 minutes and a second peak after one hour.

Apatite mimics natural bone mineral, and its formation confirms the cement's ability to mineralize in simulated physiological conditions.

It allows researchers to observe how cements convert into apatite under conditions similar to the human body.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Related Experiment Videos

Last Updated: Jun 20, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Main Methods:

The team used X-ray powder diffraction and Rietveld refinement to analyze cement phases. They prepared Sr-substituted alpha-TCP powders and hardened cements. Isothermal calorimetry tracked heat release during cement setting. Setting time was measured to understand the curing process. Cement pastes were immersed in simulated body fluid for 15 and 30 days. Scanning techniques identified apatite formation from brushite conversion. Compressive strength tests were conducted on wet cement specimens. The study combined structural analysis with mechanical performance evaluation.

Main Results:

The cements released heat within 10-15 minutes after mixing, with a second peak after one hour. Immersion in simulated body fluid led to apatite formation after 15 and 30 days. Brushite converted into apatite, confirming in vitro mineralization capability. Sr-substituted cements showed higher compressive strength than non-substituted ones. Strength decreased with longer curing times in wet specimens. The apatitic phase formation indicated successful mineralization. Heat release patterns suggested a two-stage setting process. These findings suggest Sr-substitution enhances cement performance.

Conclusions:

The authors propose that Sr-substituted alpha-TCP cements have potential for orthopedic applications. Their findings suggest that these cements support apatite formation in simulated body fluid. The two-stage heat release pattern indicates a complex setting process. Sr-substitution appears to improve compressive strength in wet conditions. The decrease in strength with curing time suggests a need for further study. The apatite formation confirms mineralization capability in vitro. These results may inform future material design for bone repair. The study highlights the role of strontium in modifying cement properties.

Sr-substituted cements showed higher compressive strength in wet conditions compared to non-substituted ones.

The authors propose that Sr-substituted cements may be suitable for orthopedic and trauma surgery to fill bone defects.