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Takayasu's arteritis associated with idiopathic ulcerative colitis
V Sakhuja1, K L Gupta, D K Bhasin
1Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Gut
|July 1, 1990
Summary
This study describes two ulcerative colitis patients with Takayasu's arteritis. Both patients presented with severe vascular issues, including limb gangrene and renovascular disease, confirmed by angiography.
Area of Science:
- Vascular Medicine
- Gastroenterology
- Rheumatology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Takayasu's arteritis (TA) is a large vessel vasculitis.
- The co-occurrence of UC and TA is rare.
Observation:
- Two patients with concurrent ulcerative colitis and Takayasu's arteritis were analyzed.
- One patient presented with limb gangrene.
- The other patient presented with renovascular disease.
Findings:
- Angiography revealed occlusions in multiple medium and large sized vessels in both patients.
- These findings suggest a potential link between UC and TA-related vascular complications.
- The specific vascular manifestations varied between the patients.
Implications:
- This case series highlights the importance of considering vasculitis in UC patients with unexplained vascular events.
- Early diagnosis and management of Takayasu's arteritis may prevent severe complications like gangrene.
- Further research is needed to elucidate the underlying mechanisms connecting these two conditions.