Development of neurotransmitter phenotypes in sympathetic neurons
Galina Apostolova1, Georg Dechant
1Institute for Neuroscience, Innsbruck Medical University, MZA, Austria. galina.apostolova@i-med.ac.at
Abstract:
This review summarizes the current understanding of neurotransmitter phenotype specification of postganglionic sympathetic neurons, focusing, in particular, on the cellular processes of induction versus trans-differentiation. The emerging evidence is discussed that the noradrenergic and cholinergic neurotransmitter phenotypes are co-induced during early development and that the mature phenotypes develop by positive and negative selection of cellular properties in initially bimodal neurons, depending on extracellular signals during migration and after target contact.
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