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11:39
Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
Published on: October 23, 2019
Cyclin D1 positive follicular lymphoma
1Ingham Regional Medical Center, Lansing, Michigan 48910, USA. brian.olsen@irmc.org
Journal of Clinical Pathology
|September 8, 2009
Summary
This case report details a rare follicular lymphoma with unusual cyclin D1 expression. Genetic analysis revealed BCL2-IGH and CCND1-IGH fusions, offering insights into lymphoma subtypes.
Area of Science:
- Hematology
- Oncology
- Molecular Pathology
Background:
- Follicular lymphoma is typically characterized by BCL2 gene rearrangement.
- Cyclin D1 expression is uncommon in low-grade follicular lymphoma.
Observation:
- An unusual case of low-grade follicular lymphoma exhibiting cyclin D1 expression was observed.
- Standard histological features of follicular lymphoma were present.
Findings:
- Interphase fluorescence in situ hybridisation (FISH) identified both BCL2-IGH and CCND1-IGH fusions.
- The co-occurrence of these genetic alterations is noteworthy.
Implications:
- This case expands the molecular understanding of follicular lymphoma heterogeneity.
- It may inform diagnostic approaches and classification of B-cell lymphomas.
- Further research into the clinical significance of combined BCL2 and CCND1 fusions is warranted.
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