Related Experiment Videos

A multi-center, double-blind, randomized controlled study of the safety and effectiveness of Juvéderm injectable gel

Susan H Weinkle, David E Bank, Charles M Boyd

    Journal of Cosmetic Dermatology
    |September 9, 2009
    PubMed
    Abstract

    Related Concept Videos

    Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

    Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

    Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
    One of the advantages of...
    Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

    Local Anesthetics: Clinical Application as Epidural Anesthesia

    Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
    Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
    Local Anesthetics: Adverse Effects01:12

    Local Anesthetics: Adverse Effects

    While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
    Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
    Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

    Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

    Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
    Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

    Local Anesthetics: Differential Sensitivity of Nerve Fibers

    Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
    Local Anesthetics: Mechanism of Action01:23

    Local Anesthetics: Mechanism of Action

    Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
    Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...