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Novel use of amantadine: to treat hiccups
Sarah K Wilcox1, Anne Garry, Miriam J Johnson
1Palliative Care Team Office, Cancer Care Centre, York Hospital, York, UK. sarahdoc_2000@yahoo.com.au
Abstract:
Persistent hiccups may have a considerable impact on general health through disturbance of diet, sleep, and mood. They can cause exhaustion, malnutrition, dehydration, wound dehiscence, and even death in extreme cases. We report a complex clinical case of intractable hiccups in a patient with cancer of the pancreas and Parkinson's disease and some of the problems encountered when attempting symptom control. We also discuss a potential therapeutic response to a novel agent, amantadine, unlicensed in the treatment of hiccups.
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