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The CD4 molecule and HIV infection.

D R Klatzmann1, J S McDougal, P J Maddon

  • 1Laboratoire de Biologie et Génétique des Infections Rétrovirales, Hôpital de la Pitié Salpétrière, Paris, France.

Immunodeficiency Reviews
|January 1, 1990
PubMed
Summary

CD4, a key immune cell surface protein, acts as the entry receptor for HIV. Researchers are developing CD4-based therapies to block HIV attachment, with some now in clinical trials for HIV patients.

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Area of Science:

  • Immunology
  • Virology
  • Biochemistry

Background:

  • CD4 (T4) is a glycoprotein found on immune cells.
  • It functions as the primary receptor for the human immunodeficiency virus (HIV).
  • Understanding CD4's structure is crucial for analyzing HIV infection and immune responses.

Purpose of the Study:

  • To analyze the structure and function of CD4.
  • To explore CD4's role in HIV pathogenesis.
  • To develop novel CD4-based therapeutics against HIV.

Main Methods:

  • Gene isolation and structural analysis of CD4.
  • Investigating CD4's interaction with HIV.
  • Development and preclinical evaluation of CD4-based therapeutics.

Main Results:

  • The structure of CD4 has been elucidated.
  • CD4's critical role in HIV entry is confirmed.
  • New therapeutic strategies targeting CD4-HIV interaction are emerging.

Conclusions:

  • CD4 is a vital target for HIV intervention.
  • CD4-based therapeutics show promise in blocking HIV infection.
  • Ongoing clinical trials are evaluating the efficacy of these novel treatments.

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