Related Experiment Video
Updated: Jun 20, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
Published on: December 1, 2023
Effect of android to gynoid fat ratio on insulin resistance in obese youth
Julien Aucouturier1, Martine Meyer, David Thivel
1Laboratory of Exercise Biology, Blaise Pascal University, Bâtiment de Biologie B, Complexe Universitaire des Cézeaux, Aubière Cedex, France.
Background:
Upper body fat distribution is associated with the early development of insulin resistance in obese children and adolescents.
Objective:
To determine if an android to gynoid fat ratio is associated with the severity of insulin resistance in obese children and adolescents, whereas peripheral subcutaneous fat may have a protective effect against insulin resistance.
Setting:
The pediatric department of University Hospital, Clermont-Ferrand, France.
Design:
A retrospective analysis using data from medical consultations between January 2005 and January 2007.
Participants:
Data from 66 obese children and adolescents coming to the hospital for medical consultation were used in this study.
Main Outcome Measures:
Subjects were stratified into tertiles of android to gynoid fat ratio determined by dual-energy x-ray absorptiometry. Insulin resistance was assessed by the homeostasis model of insulin resistance (HOMA-IR) index.
Results:
There were no differences in weight, body mass index, and body fat percentage between tertiles. Values of HOMA-IR were significantly increased in the 2 higher tertiles (mean [SD], tertile 2, 2.73 [1.41]; tertile 3, 2.89 [1.28]) compared with the lower tertile (tertile 1, 1.67 [1.24]) of android to gynoid fat ratio (P < .001). The HOMA-IR value was significantly associated with android to gynoid fat ratio (r = 0.35; P < .01).
Conclusions:
Android fat distribution is associated with an increased insulin resistance in obese children and adolescents. An android to gynoid fat ratio based on dual-energy x-ray absorptiometry measurements is a useful and simple technique to assess distribution of body fat associated with an increased risk of insulin resistance.
Related Concept Videos
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Obesity
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Type II Diabetes I: Introduction
Drug Dosing: Obese Patients
Diabetes Mellitus: Type 2 and Gestational
