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Updated: Jun 20, 2026

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
Published on: November 5, 2014
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential
Justin E Jones1, Corey P Causey, Bryan Knuckley
1University of South Carolina, Department of Chemistry & Biochemistry, Columbia, 29208, USA.
Abstract:
The protein arginine deiminases (PADs), and in particular PAD4, have emerged as potential therapeutic targets for the treatment of rheumatoid arthritis (RA). In this review, evidence linking dysregulated PAD activity to the onset and progression of RA is presented, and the potential role of such aberrant activity in other human diseases, such as multiple sclerosis and cancer, is discussed. The known physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.
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