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Clinical experiences with bronchial provocation test using oscillation technique in Chinese patients
1Department of Clinical Pathology, National Taiwan University Hospital, Taipei, R.O.C.
Journal of the Formosan Medical Association = Taiwan Yi Zhi
|February 1, 1990
Summary
Bronchial provocation tests show that 100% of asthma patients and 61% of COPD patients are responsive to methacholine. Normal subjects and restrictive lung disease patients were non-responsive, indicating airway hyperreactivity is key in these conditions.
Area of Science:
- Pulmonary Medicine
- Respiratory Physiology
Background:
- Bronchial hyperreactivity is a hallmark of asthma and COPD.
- The forced oscillation method (FOM) is used to assess respiratory resistance (Rrs).
Purpose of the Study:
- To evaluate bronchial hyperreactivity using methacholine provocation in a Chinese population.
- To differentiate responsiveness across various respiratory conditions.
Main Methods:
- 115 Chinese subjects underwent FOM with stepwise methacholine inhalation.
- Respiratory resistance (Rrs) was measured, with a >2x baseline increase defining responsiveness.
- Dose-response curves were analyzed and classified into 6 types.
Main Results:
- Asthma patients (100%) and COPD patients (61%) showed bronchial hyperreactivity.
- Normal subjects and restrictive lung disease patients were non-responders.
- Baseline Rrs was significantly higher in obstructive diseases; dose-response curve shapes varied by condition.
Conclusions:
- Methacholine provocation via FOM effectively identifies bronchial hyperreactivity in asthma and COPD.
- Distinct response patterns may aid in differential diagnosis of respiratory diseases.