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[Clinical significance of BMP-2 protein and mRNA expression in human glioma]
Ming-yu Zhang1, Jun Wu, Xin Gong
1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410078, China. hnczmy@163.com
Aim:
To investigate the expression of BMP-2 protein and mRNA in glioma, and evaluate its clinical significance in clinicopathological status of patients with glioma.
Methods:
BMP-2 protein and mRNA expression in 88 patients with glioma were examined by SABC immunohistochemistry and RT-PCR, respectively.
Results:
The positive expression rate of BMP-2 protein in glioma tissues were 78.40% (69/88), which was significantly higher (P<0.01) than that in normal brain tissues [3% (6/20)]. The expression of BMP-2 protein and mRNA in gliomas of grade III-IV was also significantly higher than that in gliomas of grade I-II.
Conclusion:
BMP-2 expression in cancerous tissues may play an important role in the progression of glioma, which may help to predict patients' prognosis as a tumor marker.
