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Updated: Jun 20, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Oncogenic EGFR signaling networks in glioma
Paul H Huang1, Alexander M Xu, Forest M White
1Protein Networks Team, Section of Cell and Molecular Biology, Institute of Cancer Research, London, UK. paul.huang@icr.ac.uk
Abstract:
The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM) initiation and progression. Here, we examine how EGFR and key downstream signaling networks contribute to the hallmark characteristics of GBM such as rapid cancer cell proliferation and diffused invasion. Additionally, we discuss current therapeutic options for GBM patients and elaborate on the mechanisms through which EGFR promotes chemoresistance. We conclude by offering a perspective on how the potential of integrative systems biology may be harnessed to develop safe and effective treatment strategies for this disease.
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