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Shuang Fang Lim1, Robert Riehn, Chih-Kuan Tung

  • 1Department of MAE, Princeton University, Princeton, NJ 08544, USA.

Nanotechnology
|September 10, 2009
PubMed
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Sub-10 nm upconverting nanoparticles (UCNPs) synthesized via combustion can be amine-modified for stable aqueous suspension and surface immobilization. These rare earth oxide UCNPs demonstrate low toxicity, making them promising for bioimaging applications.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Upconverting nanoparticles (UCNPs) convert near-infrared (NIR) photons to visible light via anti-Stokes emission.
  • NIR excitation offers deeper tissue penetration and reduced autofluorescence, beneficial for bioimaging.
  • Rare earth oxide UCNPs are a key material system for these applications.

Purpose of the Study:

  • To synthesize and characterize sub-10 nm rare earth oxide UCNPs.
  • To functionalize UCNPs for stable aqueous suspension and surface immobilization.
  • To evaluate the biocompatibility of UCNPs for bioimaging.

Main Methods:

  • Combustion synthesis of rare earth oxide UCNPs.
  • Amine modification for surface functionalization and aqueous suspension.

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  • Surface immobilization onto patterned gold surfaces.
  • Toxicity assessment using the C. elegans nematode model.

    • Main Results:

    • Successfully synthesized sub-10 nm UCNPs.
    • Achieved stable aqueous suspension of amine-modified UCNPs.
    • Demonstrated specific surface immobilization onto gold substrates.
    • Verified low toxicity of UCNPs in C. elegans.

    Conclusions:

    • Amine-modified UCNPs are suitable for bioimaging due to their size, optical properties, and low toxicity.
    • The synthesis and functionalization methods enable versatile applications in bioimaging and sensing.
    • Further development of UCNPs holds promise for advanced biomedical diagnostics.