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Diagnostic and prognostic values of critical flicker frequency determination as new diagnostic tool for objective HE
Gerald Kircheis1, Johannes G Bode, Norbert Hilger
1Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. kircheis@med.uni-duesseldorf.de
Objectives:
The diagnostic and prognostic value of critical flicker frequency (CFF) analysis for assessment of severity and dynamics of hepatic encephalopathy (HE) was studied before and after implantation of a transjugular intrahepatic portosystemic shunt (TIPS).
Basic Methods:
Sixty-three cirrhotic patients were retrospectively analyzed for the consequences of TIPS implantation. Thirty-one cirrhotic patients without TIPS implantation served as age-matched, sex-matched, Child-Pugh-matched controls. CFF and computer psychometric tests as objective test parameters of HE-severity were evaluated for analysis of visual discrimination ability, general arousal and cognitive function. Kaplan-Meier method and Cox proportional hazards regression model were used for analysis of prognostic significances.
Main Results:
In the control group, HE-severity was stable during the observation period (442+/-428 days) with minimal changes in CFF (-0.1+/-1.9 Hz). In the intervention group, TIPS implantation had no effect on HE-severity in 44% of the patients and CFF shifted by only 0.01+/-1.5 Hz. Thirty-five and 21% of the patients experienced an aggravation or improvement of HE after TIPS implantation, respectively. In HE improvers CFF increased by 3.3+/-2.3 Hz and decreased by 3.5+/-1.5 Hz in those experiencing an aggravation of HE-severity. Univariate analysis showed that overall survival in the study population inversely correlated with HE-severity and serum alkaline phosphatase activity and positively correlated with serum sodium, albumin and CFF. Serum albumin, alkaline phosphatase levels and CFF were independent predictors of survival in a multivariate Cox regression analysis.
Conclusion:
The data show that pre-TIPS HE does not predict post-TIPS encephalopathy. Otherwise, CFF can reliably pick up the evolution of HE-severity after TIPS implantation. Low pre-TIPS CFF is indicative for a poor prognosis and may help to identify transplant candidates without delay.
