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Trends in hepatitis C virus infection among patients in the HIV Outpatient Study, 1996-2007

Philip R Spradling1, James T Richardson, Kate Buchacz

  • 1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Mailstop G37, 1600 Clifton Road, NE, Atlanta, GA 30333, USA. pspradling@cdc.gov

Journal of Acquired Immune Deficiency Syndromes (1999)
|September 10, 2009
PubMed

Insights

Hepatitis C virus (HCV) screening improved in HIV patients, with prevalence decreasing overall. However, injection drug users (IDUs) saw no decline, highlighting ongoing challenges in HCV coinfection management.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Public Health

Background:

  • Hepatitis C virus (HCV) coinfection significantly increases morbidity and mortality in individuals with human immunodeficiency virus (HIV).
  • Understanding screening practices and prevalence trends is crucial for managing HIV/HCV coinfection.

Purpose of the Study:

  • To assess trends in HCV infection screening practices among HIV-infected patients.
  • To determine changes in HCV infection prevalence within the HIV Outpatient Study (HOPS) cohort between 1996 and 2007.

Main Methods:

  • Analysis of patient data from the HOPS cohort (1996-2007).
  • Calculation of annual HCV testing eligibility and prevalence rates.
  • Logistic regression to identify factors associated with HCV testing.

Main Results:

  • HCV testing eligibility increased from 10.7% to 76.6% between 1996 and 2007.
  • Overall HCV prevalence decreased from 36.7% to 19.7% during the study period.
  • Prevalence declined in most groups, but not among injection drug users (IDUs); IDUs were a primary driver of prevalent infections.

Conclusions:

  • HCV screening in the HOPS cohort demonstrated significant improvement.
  • Despite improved screening, a substantial portion of patients remained untested for HCV.
  • The decline in HCV prevalence was largely attributed to factors other than injection drug use.
Abstract

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