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[Complex treatment of acute hematogenous osteomyelitis in children]

S V Minaev, R A Motorina, V V Leskin

    Khirurgiia
    |September 10, 2009
    PubMed

    Insights

    Acute hematogenous osteomyelitis in children is a significant challenge. Adding Licopid to standard therapy reduced inflammatory markers like TNF-alpha and IL-1beta, improving treatment outcomes.

    Area of Science:

    • Pediatric Surgery
    • Immunology
    • Infectious Diseases

    Background:

    • Acute hematogenous osteomyelitis presents significant challenges in pediatric surgery due to its severe course, diagnostic difficulties, and potential for chronic complications.
    • Early diagnosis and effective treatment are crucial to prevent long-term adverse outcomes in children.

    Purpose of the Study:

    • To investigate the efficacy of Licopid as an adjunct to standard therapy in treating acute hematogenous osteomyelitis in children.
    • To evaluate the impact of Licopid on key inflammatory markers, including C-reactive protein (CRP), Interleukin-1 beta (IL-1beta), and Tumor Necrosis Factor-alpha (TNF-alpha).

    Main Methods:

    • A study involving 74 children diagnosed with acute hematogenous osteomyelitis.
    • Two groups were established: a control group receiving standard therapy and a main group receiving standard therapy plus Licopid.
    • Levels of CRP, IL-1beta, and TNF-alpha were measured in both groups at specified time points.

    Main Results:

    • The main group treated with Licopid showed a significant reduction in TNF-alpha levels by day 14 compared to the control group (p<0.01).
    • While IL-1beta levels decreased in the main group over time, the difference compared to the control group at day 14 was not statistically significant.
    • CRP levels were higher in the main group at day 14 (22.9 mg/ml) compared to the control group (12.9 mg/ml), suggesting a complex inflammatory response or different resolution kinetics.

    Conclusions:

    • The combined treatment of acute hematogenous osteomyelitis with Licopid demonstrated positive therapeutic results in pediatric patients.
    • Licopid may play a role in modulating the inflammatory response, warranting further investigation into its specific mechanisms and optimal use in pediatric osteomyelitis.

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