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Related Experiment Video

Updated: Jun 20, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

[Pseudo-conduction block in nonsystemic vasculitic neuropathy].

R M Pabón Meneses¹, L Gila, J Urriza

¹Servicio de Neurofisiología Clínica, Hospital Virgen del Camino, Pamplona, 31008, Spain.

Anales Del Sistema Sanitario De Navarra

|September 10, 2009

Summary

Nonsystemic vasculitic neuropathy (NSVN) can initially mimic conduction block on nerve studies. Early diagnosis requires repeated neurophysiologic assessments to differentiate transient pseudo-conduction block from permanent axonal damage.

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Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

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Published on: August 27, 2019

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Last Updated: Jun 20, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

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Published on: November 21, 2025

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

Area of Science:

Neurology
Vascular Medicine
Neurophysiology

Background:

Nonsystemic vasculitic neuropathy (NSVN) is an inflammatory condition affecting the vasa nervorum, typically presenting as mononeuritis multiplex.
Early detection and characterization of NSVN are crucial for timely intervention and management.

Observation:

A 36-year-old woman presented with sensory and motor deficits in her right hand and left foot.
Initial neurophysiologic examination revealed low amplitude of the right median nerve compound muscle action potential (CMAP) with proximal stimulation.
Subsequent examination demonstrated evidence of axonal damage in multiple nerves, including the right median nerve.

Findings:

Acute ischemic nerve damage in NSVN can manifest as a conduction block pattern on electroneurography.
This pattern, termed "pseudo-conduction block," is transient and can evolve into axonal neuropathy.
The case highlights the importance of serial neurophysiologic studies for accurate diagnosis.

Implications:

Recognizing pseudo-conduction block is vital for differentiating early NSVN from other neuropathies.
Repeated neurophysiologic evaluations are essential for comprehensive characterization of vasculitic neuropathy.
This case underscores the diagnostic utility of electrophysiologic testing in early-stage NSVN.