Related Experiment Video
Updated: Jun 20, 2026

Epithelial Cell Infection Analyses with Shigella
Published on: February 9, 2024
Acute infectious diarrhea in children
Sibylle Koletzko1, Stephanie Osterrieder
1Abteilung für Pädiatrische Gastroenterologie und Hepatologie, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität München. Sibylle.Koletzko@med.uni-muenchen.de
Insights
Acute infectious enteritis in children is common, but treatment guidelines are often not followed. Oral rehydration solution (ORS) effectively treats dehydration in over 90% of cases, avoiding IV fluids.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- Acute infectious enteritis is a prevalent childhood illness globally, particularly affecting children under three.
- In Germany, one in six children under five consults a physician for infectious diarrhea annually.
- Rotavirus infection leads to hospitalization in 10% of affected children.
Purpose of the Study:
- To review current national and international guidelines for treating acute infectious diarrheal disease in children.
- To emphasize the importance of adhering to evidence-based treatment recommendations.
- To highlight effective rehydration strategies for pediatric gastroenteritis.
Main Methods:
- A selective literature search was conducted.
- The search focused on national and international guidelines for managing infectious diarrhea.
- Evidence-based recommendations were synthesized.
Main Results:
- The primary therapeutic objective is to restore fluid and electrolyte balance disrupted by diarrhea and vomiting.
- Hypotonic oral rehydration solution (ORS) is recommended for impending or existing mild-to-moderate dehydration.
- Frequent, small oral administrations of ORS over 3-4 hours achieve success in over 90% of cases.
Conclusions:
- Oral rehydration with ORS is a highly effective treatment for pediatric diarrhea and vomiting.
- Regular feeding can resume immediately after successful oral rehydration.
- Intravenous fluid administration should be avoided in children who can be rehydrated orally or via nasogastric tube; laboratory testing is typically unnecessary.
Background:
Acute infectious enteritis is one of the more common childhood diseases worldwide, especially in the first three years of life. Every year, in Germany, one in six children under age 5 is taken to a physician at least once because of infectious diarrheal disease. 10% of the children presenting with rotavirus infection are admitted to hospital. The existing national and international recommendations for the treatment of acute infectious diarrheal disease are inadequately followed, despite the high level of evidence on which they are based.
Methods:
Selective literature search based on national and international guidelines.
Results And Conclusions:
The therapeutic goal is to replace the fluid and electrolyte losses resulting from diarrhea and vomiting. The administration of a hypotonic oral rehydration solution (ORS) is indicated to treat impending dehydration (infants aged up to 6 months with diarrhea and/or more than 8 watery stools in the last 24 hours and/or more than 4 episodes of vomiting in the last 24 hours), or when mild or moderate dehydration is already present. Oral rehydration with ORS given in frequent, small amounts over 3-4 hours is successful in more than 90% of cases. Regular feeding can be begun immediately afterward. Laboratory testing of blood or stool is usually unnecessary. Children who can be rehydrated orally or through a nasogastric tube should not be given intravenous fluids.
Related Concept Videos
Bacterial Gastroenteritis
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Giardiasis
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Cholera
Acute Pyelonephritis I: Introduction
