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Related Experiment Video

Updated: Jun 20, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

[Primary bone anaplastic large cell lymphoma].

Gabriel Juan Mandujano-Alvarez¹, Francisco Moreno-Sánchez, Manuel Morales-Polanco

¹Departamento de Patologia, Centro Médico, ABC.

Acta Ortopedica Mexicana

|September 11, 2009

Summary

Anaplastic large cell lymphoma (ALCL) rarely affects bone. This case highlights a rare instance of ALCL presenting solely with bone lesions, emphasizing diagnostic challenges and the role of Glut-1 expression in PET-CT imaging.

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Last Updated: Jun 20, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Area of Science:

Hematology
Oncology
Pathology

Background:

Anaplastic large cell lymphoma (ALCL) is a T-cell or null-cell neoplasm, comprising 3% of adult non-Hodgkin lymphomas.
While ALCL commonly affects lymph nodes and extranodal sites, primary bone involvement is exceptionally rare.

Observation:

A 47-year-old male presented with multifocal bone lesions (vertebrae, ribs, iliac bone) as the sole site of disease.
Histopathology revealed interstitial and focal bone infiltrate with large pleomorphic cells, inflammation, and fibrosis.
Immunohistochemistry showed expression of CD30, EMA, CD45RO, CD43, CD8, Glut-1, and ALK-1.

Findings:

This case represents one of only 20 reported instances of ALCL (T/null cell) originating in bone.
Distinguishing primary bone lymphoma requires excluding systemic lymphoma with bone metastasis.
FDG uptake on PET-CT correlated with Glut-1 expression, aiding in differential diagnosis.

Implications:

This case underscores the importance of considering rare presentations of ALCL in the differential diagnosis of bone lesions.
Accurate diagnosis is crucial, necessitating exclusion of systemic disease and consideration of entities like osteomyelitis and other bone tumors.
Glut-1 expression may serve as a useful biomarker in the PET-CT evaluation of bone lymphomas.