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Neuroendocrine effects of azapirones
P J Cowen1, I M Anderson, D G Grahame-Smith
1Medical Research Council Unit of Clinical Pharmacology, Radcliffe Infirmary, Oxford, England.
Journal of Clinical Psychopharmacology
|June 1, 1990
Summary
Azapirones, including buspirone, alter endocrine function by affecting serotonin (5-hydroxytryptamine, 5-HT) receptors. These drugs impact cortisol, prolactin, growth hormone, and body temperature in healthy individuals.
Area of Science:
- Neuroendocrinology
- Pharmacology
Background:
- Azapirones are a class of drugs known to affect neurotransmitter systems.
- Previous research indicates azapirones influence endocrine markers and body temperature in humans and animals.
Purpose of the Study:
- To investigate the endocrine and physiological effects of azapirones in healthy volunteers.
- To explore the role of serotonin 5-HT1A receptors in mediating these effects.
Main Methods:
- Administration of azapirones (buspirone, ipsapirone, gepirone) to healthy human subjects.
- Measurement of plasma cortisol, prolactin, and growth hormone levels.
- Monitoring of body temperature changes.
Main Results:
- Azapirones increased plasma cortisol and decreased body temperature.
- Buspirone and gepirone also elevated plasma prolactin and growth hormone.
- Animal studies suggest serotonin (5-hydroxytryptamine, 5-HT) 1A receptor stimulation mediates some effects.
Conclusions:
- Azapirones exert significant effects on human endocrine function and thermoregulation.
- Serotonin 5-HT1A receptors are implicated in the observed physiological responses.
- Further research with selective antagonists is needed to fully elucidate the mechanisms involved.