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Updated: Jun 20, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Nickel-catalyzed cycloadditive couplings of enynes and isocyanates
Brendan R D'Souza1, Janis Louie
1University of Utah, 315 S. 1400 E, Salt Lake City, Utah 84112, USA.
Abstract:
A mild and general route for preparing dienamides is described. Nickel imidazolylidene complexes were used to mediate cycloadditive coupling between enynes and isocyanates. Dienamides were prepared in excellent yields and with good E:Z selectivity. These dienamides can be further manipulated through oxidative cyclization methods. When a terminal enyne is employed, cyclization affords a lactam rather than a dienamide.
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