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Cardiac amyloidosis and Brugada-like ECG pattern
Dimitrios Bramos1, Konstantinos Koutras1, George Kollias1
1Second Department of Cardiology, Evangelismos General Hospital of Athens, 10676, Athens, Greece.
International Journal of Cardiology
|September 11, 2009
Summary
Brugada syndrome, a heart rhythm disorder, is linked to cardiac amyloidosis. This case highlights potential structural heart changes in Brugada syndrome, connecting it to multiple myeloma.
Area of Science:
- Cardiology
- Electrophysiology
- Genetics
Background:
- Brugada syndrome is an inherited channelopathy causing dangerous heart rhythms and sudden cardiac death.
- It typically affects individuals with structurally normal hearts.
- Emerging evidence suggests subtle structural changes, particularly in the right ventricle, may occur.
Observation:
- A patient with cardiac amyloidosis secondary to multiple myeloma presented with concerning symptoms.
- The patient experienced pre-syncopal episodes, indicating potential cardiac dysfunction.
- An electrocardiogram (ECG) revealed an intermittent Brugada-like pattern.
Findings:
- This case suggests a potential association between cardiac amyloidosis from multiple myeloma and Brugada-like ECG findings.
- The presence of amyloidosis may contribute to or mimic the structural changes seen in Brugada syndrome.
- The intermittent Brugada-like pattern in this context requires further investigation.
Implications:
- Cardiac amyloidosis should be considered in the differential diagnosis of patients presenting with Brugada-like ECG patterns.
- This finding may expand our understanding of the spectrum of Brugada syndrome and its potential underlying causes.
- Further research is needed to elucidate the mechanisms linking amyloidosis to ventricular arrhythmias and ECG abnormalities.
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