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Updated: Jun 20, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
Recurrent form of neurogenic stunned myocardium: is myocardial adrenergic receptor distribution a dynamic process?
O Morel1, L Jesel1, S Cimarelli2
1Pôle d'activité médico-chirgicale cardio-vasculaire des Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, France.
Abstract:
Neurogenic stunned myocardium mediated by stress-induced catecholamine acute release is considered as the central causative mechanism of transient left ventricular dysfunction syndrome (TVLDS). Interindividual differences in both LV β-adrenergic receptor density and sympathetic innervation were proposed to explain the atypical forms of TVLDS. Whether this distribution is independent of age or may vary during ageing still remains unclear. We report a recurrent form of TLVDS characterized by two different patterns. Whilst myocardial receptor distribution or sympathetic innervation appears to follow a dynamic process, the precise determinants of these variations remain largely unknown.
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