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Updated: Jun 20, 2026
11:01
RNA-Associated Chromatin DNA-DNA Interaction Method
Published on: April 30, 2026
Three-way RNA junctions with remote tertiary contacts: a recurrent and highly versatile fold
Marcos de la Peña1, David Dufour, José Gallego
1Instituto de Biología Molecular y Celular de Plantas (UPV-CSIC), 46022 Valencia, Spain.
RNA (New York, N.Y.)
|September 11, 2009
Summary
Y-shaped RNA junctions form a common structural motif. These structures are crucial for RNA function and assembly across all life forms, acting as versatile platforms for molecular interactions.
Area of Science:
- Structural biology
- Molecular biology
- RNA biology
Background:
- Three-way junction RNAs commonly adopt a Y-shape.
- This structure involves coaxial stacking of two helices and tertiary contacts from a third helix.
Purpose of the Study:
- To review the structure, distribution, and functional relevance of Y-shaped RNA motifs.
- To examine their role in RNA and ribonucleoprotein systems.
Main Methods:
- Review of existing literature on RNA structure and function.
- Analysis of conserved junction topologies and tertiary interactions.
- Examination of functional roles in various biological contexts.
Main Results:
- Y-shaped folds exhibit conserved junction topologies.
- Distal tertiary interactions are critical for determining structural shape.
- These junctions act as flexible hinges, enabling switching mechanisms.
- They provide platforms for specific binding by proteins, RNA, and antibiotics.
- Y-shaped junctions are widespread in all kingdoms of life.
Conclusions:
- Y-shaped RNA junctions are essential for the function and assembly of diverse RNA and ribonucleoprotein systems.
- Their unique structural properties facilitate critical molecular interactions.
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