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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
New paradigms in the pathogenesis of chronic obstructive pulmonary disease I
William MacNee1, Rubin M Tuder
1University of Edinburgh, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK. w.macnee@ed.ac.uk
Abstract:
This paper reviews the potential participation of novel pathogenic mechanisms in chronic obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and enhanced expression of markers of senescence in emphysematous lungs and the potential enhanced tissue destruction involving alveolar apoptosis. These insights provide new beginnings for future investigations in the pathobiology of COPD which may lead to future therapies for this condition.
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